Background: Based on data from the Health Profile of Indonesia DHF incidence in 2015 recorded the dengue fever rate of 50.75 per 10.000 population and the mortality rate (0.83%). This study aims to analyze the relationship between Education and socio-economic status of community in Wetland Areas with the incidence of Dengue Haemorrhagik fever (DHF). Materials and Methods: This research is a quantitative research using case control design. The population in this study were all dengue sufferers and did not suffer dengue in the working area of ​​ Primary Health Center Guntung Manggis. Researched sample amounted to 108 respondents using simple random sampling technique with 1:2 ratio of 36 respondents and control sample 72 respondents using questioner instrument with chi square test. Result: Research shows that risk factors related to DHF incidence are education (P-Value = 0,001), job status (P-Value = 0,044), and income (P-Value=0,007). Conclusion: Educational variables, and socioeconomic status (job status. and income) are risk factors of Dengue Haemorrhagik fever (DHF) in Wetland Areas