Faculty of Public Health - Andalas University - OCS, 13th IEA SEA Meeting and ICPH - SDev

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POLYMORPHISM OF TMPRSS6 GENE AND IRON INTAKE ARE BOTH ASSOCIATED WITH IRON STATUS AMONG UNDER-TWO-YEAR- OLD CHILDREN IN LOMBOK, INDONESIA
Dewi Shinta

Last modified: 2018-08-16

Abstract


Background

Multiple common variants in transmembrane protease serrin 6 (TMPRSS6) were associated with plasma iron concentration in genome-wide association studies, but their effect in children particularly where anemia and iron deficiency (ID) were prevalent has not been reported. Iron intake is also known to be associated iron status however no studies have assessed the contribution of both iron intake and gene to iron status. This study aims to investigate whether TMPRSS6 SNPs (rs855791 and rs4820268) and iron intake are associated with low iron and hemoglobin concentration.

Materials and methods

The study analysed baseline of randomized trial (NUPICO, clinical-trials. gov NCT01504633) in East Lombok, Indonesia. Children aged 6-17 months (n=121) were included in this study.

 

Results

Multiple linear regression showed that TMPRSS6 decreased SF by 4.50 g/L per copy minor allele (A) of rs855791 (p = 0.08) and by 5.00 μg/L per copy minor allele (G) of rs4820268 (p = 0.044). There were no associations between rs855791 and rs4820268 with soluble transferrin receptor (sTfR) and hemoglobin (Hb) concentration (rs855791; p = 0.37 and p = 0.13, rs4820268; p = 0.17 and p = 0.33). Iron intake was also associated with SF and its significance is stronger as compared to TMPRSS6 genotype (p = 0.007 and p = 0.009).

 

 

Conclusions

The finding suggests the need for further studies to explore if nutrient recommendations should be based on genetic characteristics particularly for children who have mutation in TMPRSS6.

 

Acknowledgements

This study was funded by Ministry of Education Government of Indonesia (SEAMEO RECFON DIPA 2015), Scientific Programme Indonesia Netherlands Academy of Arts and Sciences (SPIN-KNAW) (Award Letter 09-PD-12), Beasiswa Pendidikan Indonesia Lembaga Pengelolaan Dana Pendidikan (BPI-LPDP) (no. 20160822028741). The authors are grateful to Dr. Dwi Anita Suryandari, Dr. Luh Ade Wiradnyani for their suggestion for the study; Dr. Judhiastuty Februhartanty for technical editing, Putu Amrytha Sanjiwani and Ria Amelia for their assistance in the laboratory. We particularly like to thank all the participants, voluntary health workers and local leaders in Suralaga sub-district, East Lombok District, West Nusa Tenggara Indonesia for their cooperation.

 

Key Words: Iron status, TMPRSS6, iron intake, children, Indonesia