Faculty of Public Health - Andalas University - OCS, 13th IEA SEA Meeting and ICPH - SDev

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Community Sero-prevalence of Hepatitis B in India: A review and meta-analysis
Pratap Kumar Jena

Last modified: 2018-08-07


Background : This study estimates the pooled sero-prevalence of Hepatitis B in India.

Materials and methods : Community studies conducted during last 10 years assessing sero-prevalence HBV were included in this meta-analysis. PRISMA guidelines were followed to select articles. Studies involving high-risk groups and hospital settings were excluded. Ten selected studies were analyzed using MetaXL (v.5.3) software. Inverse Variance Heterogeneity model was used for estimating pooled prevalence.


Results : Included studies covered around 38 thousand populations. The HBV sero-prevalence awareness in the included studies in this meta-analysis was ranged between 0.5% to 22.5% percent of the studied population. The pooled sero-prevalence of HBV was 2.63% (95% CI: 0% - 11.8%). Because of limited gender stratified information in these studies, pooled sero-prevalence of HBV among males and females couldn’t be estimated. Studies included were of moderate quality and there was heterogeneity among studies.


Conclusions : Overall HBV sero-prevalence in community setting in India is low but considering population size, it can be translated into approx. 33 million HBV infected individuals. This poses enormous challenge to the Indian health system in terms of vaccine coverage, treatment of infected cases and future planning for care of hepatocellular carcinoma individuals. Efforts to improve the birth dose of hepatitis B should be seriously considered.


Acknowledgement : Dr. Parimala Mohanty, Dr. Nancy Satpathy, Dr. Jyoti Kumari, Dr. Rasmi Gadtia of KSPH, KIIT Deemed to be University


Keywords) :  Hepatitis B, sero-prevalence, India