Faculty of Public Health - Andalas University - OCS, 13th IEA SEA Meeting and ICPH - SDev

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Pattern of extra-articular manifestations among rheumatoid arthritis patients: A hospital based cross-sectional study
Bhaskar Thakur, Prashanta Padhan, Mona Pathak

Last modified: 2018-09-16



Rheumatoid Arthritis (RA) is a systemic disease involving joints inflammation, affecting 1-2% of general population. Extra articular disease is single most important cause of morbidity and mortality in RA. It is characterised by destructive polyarthritis and extra-articular organ involvement which includes skin, eye, heart, lung, renal, nervous and gastrointestinal systems. Prevalence of such involvement differs from one country to another country. Accordingly, pattern of extra-articular manifestations (EAM) was investigated in a tertiary care hospital in India.

Materials and methods

Under the hospital based coos-sectional study, patients were diagnosed with rheumatoid arthritis using standard guidelines at Kalinga Institute of medical Sciences, Orissa, India and pattern of EAM was recorded.


Out of 208 RA patients, anemia occurred in 110 (53%), kcs keratoconjunctivitis sicca in 28 (13.46%), Lymphadenopathy in 20 (9.6%), Interstitial lung disease in 17 (8.17%), Carpal tunnel syndrome in 14 (6.73%), RA skin nodules in 13 (6.25%). Frequency of other syndromes such as fever, thrombocytosis,  coronary artery disease, mononeuritis multiplex were 3.4%, 2%, 1% and 1% respectively.  Frequency for rest of the other EAM organ such as scleromalacia, pleurisy pleural effusion and valvular heart disease were found only in single patient (0.5%).



EAM were present substantially in our RA patients, which may further lead to a worse disease outcome. Anemia, followed by kcs keratoconjunctivitis sicca, lymphadenopathy, interstitial lung disease, Carpal tunnel syndrome and RA skin nodules were the commonest. Early recognition of EAM and further treatment may be more important to decrease the severe morbidity and mortality.