Faculty of Public Health - Andalas University - OCS, 13th IEA SEA Meeting and ICPH - SDev

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Impact of thyroid dysfunction on metabolic syndrome
Priyanka Sahu, Chandra Mani Pandey, Sonam Bedi

Last modified: 2018-09-16

Abstract


Impact of thyroid dysfunction on metabolic syndrome

Priyanka Sahu1, C. M. Pandey2, Sonam Bedi3

1 Department of Community Medicine, Prasad Institute of Medical Sciences, Lucknow, India

2 Department of Biostatistics and Health Informatics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

3 Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

 

Background

Metabolic syndrome (Mets) is associated with endocrine disorders including thyroid dysfunction. Thyroid dysfunction in MetS patients adds to chronic diseases thereby increasing mortality. The present case control study was undertaken to determine the impact of thyroid dysfunction on MetS and finding the risk factor of Mets.

 

Methodology

The present study consisted of 600 subjects, 300 each cases and controls of MetS. Information on demographics, clinical profile and laboratory parameters like age, gender, blood pressure, blood sugar, cholesterol level, etc. were collected in both cases and controls. Mean levels of thyroid function parameters between cases and controls were compared using T test and binary logistic regression was used to find the risk factors of MetS.

Results

The levels of T3, T4 TSH, FT3, FT4 are significantly different between cases and controls whereas age, body mass index are same in cases and controls. Thyroid dysfunction was seen in 54.7% (n = 300) MetS patients. Subclinical hypothyroidism (24%) was the major thyroid dysfunction followed by hypothyroidism (18.33%), hyperthyroidism (6.67%) and subclinical hyperthyroidism (5.67%). T3, T4, TSH and FT3 came out to be as risk factors of MetS and FT3 was a protective factor (β=-0.681).

 

Conclusion

Thyroid dysfunction causes metabolic syndrome.

 

Keywords: Metabolic syndrome, Thyroid dysfunction, Logistic regression